Ivermectin treatment in lactating mares results in suboptimal ivermectin exposure in their suckling foals
نویسندگان
چکیده
The management of equine strongyles has become problematic over the last decade because an increased prevalence drug-resistant isolates worldwide. Therapeutic options are therefore limited, leaving macrocyclic lactones as most often effective drug class. However, their lipophilic properties result in a long-lasting elimination that could favour resistance selection. As result, ivermectin treatment lactating mares promote suboptimal exposure foal parasites to ivermectin, thereby selecting for more resistant worms. To test this putative transfer, we selected two groups six foal-mare pairs, one group receiving and other being left untreated. We compared faecal egg count trajectories foals from quantified plasma concentrations treated during seven days. Our results showed limited but sustained plasmatic associated with non-significant reduction (P = 0.69). This suggests foal.
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ژورنال
عنوان ژورنال: Veterinary Parasitology
سال: 2021
ISSN: ['1873-2550', '0304-4017']
DOI: https://doi.org/10.1016/j.vetpar.2021.109511